![]() We have recently demonstrated differential expressions of CXCR3 variants in endometriosis and ovarian cancers. Ovarian cancer develops occasionally on the bases of endometriosis, a chronic inflammatory disease. Tumor- associated macrophages (TAMs) contribute to angiogenesis and immune suppression by modulating microenvironment. Inflammatory cells play important roles in progression of solid neoplasms including ovarian cancers. Impaired CXCL4 expression in tumor- associated macrophages (TAMs) of ovarian cancers arising in endometriosis.įuruya, Mitsuko Tanaka, Reiko Miyagi, Etsuko Kami, Daisuke Nagahama, Kiyotaka Miyagi, Yohei Nagashima, Yoji Hirahara, Fumiki Inayama, Yoshiaki Aoki, Ichiro The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions. By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. Overall we observed 15 significant burden statistics, which was three times more than expected. There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Endometriosis-associated genetic variation and ovarian cancer. ![]() Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies. To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer. Lee, Alice W Templeman, Claire Stram, Douglas A Beesley, Jonathan Tyrer, Jonathan Berchuck, Andrew Pharoah, Paul P Chenevix-Trench, Georgia Pearce, Celeste Leigh Evidence of a genetic link between endometriosis and ovarian cancer.
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